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DTSTAMP:20250514T152727Z
DESCRIPTION:Evolution of chromosome arm aberrations in breast cancer throug
 h genetic network rewiring \n\nElena Kuzmin\, Concordia University\n	Tuesda
 y September 26\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/86855481591\n
 	In Person: 550 Sherbrooke\, Room 189\n	\n	Abstract: The basal breast cancer 
 subtype is enriched for triple-negative breast cancer (TNBC) and displays 
 consistent large chromosomal deletions. I will tell you about how we chara
 cterized the evolution and maintenance of chromosome 4p (chr4p) loss in ba
 sal breast cancer. TCGA data analysis showed recurrent deletion of chr4p i
 n basal breast cancer. Phylogenetic analysis of a unique panel of 23 prima
 ry tumor/patient-derived xenograft basal breast cancers revealed early evo
 lution of chr4p deletion. Mechanistically we show that Chr4p loss is assoc
 iated with enhanced proliferation. Gene function studies identified an unk
 nown gene\, C4orf19\, within chr4p\, which suppressed proliferation when o
 verexpressed and is a novel member of a PDCD10-GCKIII kinase module\, we n
 ame as PGCA1. Genome-wide pooled overexpression screens using a barcoded l
 ibrary of human open reading frames\, identified chromosomal regions\, inc
 luding chr4p\, that suppress proliferation when overexpressed in a context
 -dependent manner implicating network interactions. Together this sheds li
 ght on the early emergence of complex aneuploid karyotypes involving chr4p
  and adaptive landscapes shaping breast cancer genomes.\n
DTSTART:20230926T160000Z
DTEND:20230926T170000Z
SUMMARY:QLS Seminar Series - Elena Kuzmin
URL:/qls/channels/event/qls-seminar-series-elena-kuzmi
 n-350779
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