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UID:20250803T163702EDT-1677hdbpAR@132.216.98.100
DTSTAMP:20250803T203702Z
DESCRIPTION:Computational Modeling of Intracellular Dynamics\n\nJames R. Fa
 eder\, Department of Computational and Systems Biology\, University of Pit
 tsburgh\n	Tuesday November 8\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/
 86855481591\n\nAbstract: My research is focused on the mathematical and co
 mputational modeling of cell regulatory processes. We and others have deve
 loped an approach to modeling the reaction kinetics of biochemical systems
  that allows detailed knowledge about protein-protein interactions to be e
 ncoded as rules that generalize the standard reaction network formulation 
 and enables the building\, simulation\, and analysis of models in a scalab
 le and precise manner. Using this rule-based approach\, we developed found
 ational models of early events in immunoreceptor and growth factor signali
 ng that allowed us to investigate the mechanistic roles of specific intera
 ction domains and phosphorylation sites. My group currently leads the deve
 lopment of widely-used software tools that enable rule-based modeling\, an
 d we develop models employing these methods across a wide range of biologi
 cal processes including immune signaling\, viral replication dynamics\, an
 d signaling pathways in cancer. In each of these applications a significan
 t focus of our work is on the development of novel drug combinations and o
 ther intervention strategies to treat human disease.\n
DTSTART:20221108T170000Z
DTEND:20221108T180000Z
SUMMARY:QLS Seminar Series - James Faeder
URL:/qls/channels/event/qls-seminar-series-james-faede
 r-343271
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