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DTSTAMP:20250803T084216Z
DESCRIPTION:From Neanderthals to COVID-19: genetic and evolutionary sources
  of immune response variation in humans\n\nLluis Quintana-Murci - Pasteur 
 Insitute\n	Tuesday May 17\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/854
 28056343\n\nAbstract: Immune response is one of the functions that have be
 en more strongly targeted by natural selection during human evolution. The
  evolutionary genetic dissection of the immune system has greatly helped t
 o distinguish genes and functions that are essential\, redundant or advant
 ageous for human survival. It is also becoming increasingly clear that anc
 ient admixture between early Eurasians with now-extinct hominins such as N
 eanderthals or Denisovans\, or modern admixture between human populations\
 , can be beneficial for human adaptation to environmental cues\, including
  pathogen pressures. I will focus on how integrating population genetics a
 nd functional genomics of contemporary humans with ancient DNA from both a
 ncient humans and extinct hominins — including ancient DNA data from diffe
 rent epochs — can inform about key immunological mechanisms of host defens
 e and the detection of natural selection in real time. Furthermore\, I wil
 l present our most recent data on the dissection of the genetic and evolut
 ionary factors driving variation in human immune responses to respiratory 
 RNA viruses\, including SARS-CoV-2 and influenza A virus. Collectively\, o
 ur results suggest that\, while environmentally-driven differences in cell
 ular composition are a major contributor to population variation in immuni
 ty to infection\, genetic ancestry and adaptive evolution have also played
  a critical role in the differentiation of immune responses to viruses pre
 sently observed across major continental groups.\n
DTSTART:20220317T160000Z
DTEND:20220317T170000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar - Lluis Quintana-Murci
URL:/qls/channels/event/qls-seminar-lluis-quintana-mur
 ci-339135
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