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UID:20250802T182055EDT-05432DMJ4A@132.216.98.100
DTSTAMP:20250802T222055Z
DESCRIPTION:Genomic inbreeding and its contribution to the study of human d
 iseases\n\nAnne-Louise Leutenegger\, Inserm NeuroDiderot\n	Tuesday April 13
 \, 12-1pm\n	Zoom Link: https:/mcgill.zoom.us/j/91589192037\n\nAbstract: Cou
 ples of close relatives (second cousins or closer) and their offspring rep
 resent about 10% of the world population. Related individuals are individu
 als who have at least one ancestor in common. The genetic consequence of t
 his shared ancestry is that alleles may be received identical by descent (
 IBD) from one of the ancestors. These IBD alleles may be shared between in
 dividuals (relatedness) or within an individual (inbreeding).\n\nHistorica
 lly the estimation of relatedness and inbreeding has been done relying on 
 pedigree information. But with the advent of high throughput technologies 
 allowing to produce large amounts of genomic information\, reliable estima
 tion from the genome can now be obtained.\n\nI will first present how this
  dense genomic information can be used to estimate inbreeding\, how it dif
 fers from the information provided by pedigrees and which inference models
  are used and their relative merits. I will then present how these develop
 ments have been of interest for disease gene mapping.\n
DTSTART:20210413T160000Z
DTEND:20210413T170000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Anne-Louise Leutenegger
URL:/qls/channels/event/qls-seminar-series-anne-louise
 -leutenegger-330309
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