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DESCRIPTION:From circadian clock mechanism to sleep disorders and jet lag: 
 Insights from a computational approach\n\nAlbert Goldbeter\, Université Li
 bre de Bruxelles\n	Tuesday March 9\, 12-1pm\n	Zoom Link: https:/mcgill.zoom.
 us/j/91589192037\n\nAbstract: We present ten insights gained from a comput
 ational approach to the molecular mechanism of the mammalian circadian clo
 ck. These insights pertain to (1) the conditions in which circadian rhythm
 s occur spontaneously\, with a period close to 24h\, in the form of limit 
 cycle oscillations\, (2) circadian clock entrainment by the light-dark (LD
 ) cycle\, (3) the dynamical bases of sleep-wake cycle disorders related to
  the circadian-clock\, and (4) jet lag. The sleep disorders include the fa
 milial advanced sleep phase syndrome (FASPS)\, the delayed sleep phase syn
 drome (DSPS)\, and the non-24h sleep-wake cycle syndrome\, in which the ph
 ase of the circadian clock drifts in the course of time. In regard to jet 
 lag\, the computational approach accounts for two modes of re-entrainment 
 observed after a phase shift in the LD cycle and reveals conditions in whi
 ch the resynchronization of the circadian clock may take a very long time.
  Repetitive perturbations of the circadian clock due to chronic jet lag ma
 y lead to irregular or even chaotic oscillations.\n\nReferences\n\nJ-C. Le
 loup\, A. Goldbeter (2003) Toward a detailed computational model for the m
 ammalian circadian clock\, Proc. Natl. Acad. Sci. USA 100\, 7051-7056.\n\n
 J.-C. Leloup\, A. Goldbeter (2004) Modeling the mammalian circadian clock:
  Sensitivity analysis and multiplicity of oscillatory mechanisms\, J. Theo
 r. Biol. 230\, 541-562.\n\nJ.-C. Leloup\, A. Goldbeter\, (2008) Modeling t
 he circadian clock : From molecular mechanism to physiological disorders. 
 BioEssays 30\, 590-600.\n\nJ.-C. Leloup\, A. Goldbeter (2013) Critical pha
 se shifts slow down circadian clock recovery: Implications for jet lag\, J
 . Theor. Biol. 333\, 47-57.\n\nA. Goldbeter\, J.-C. Leloup\, (2021) From c
 ircadian clock mechanism to sleep disorders and jet lag: Insights from a c
 omputational approach\, Biochemical Pharmacology\, in press.\n
DTSTART:20210309T170000Z
DTEND:20210309T180000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Albert Goldbeter
URL:/qls/channels/event/qls-seminar-series-albert-gold
 beter-328517
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