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DESCRIPTION:3D imaging and quantification of synthetic and natural biominer
 alization systems: Growing and analyzing biorocks\n\nMarc D McKee\, 91µ¼º½ÊÓƵ
  University\n	Tuesday November 5\, 12-1pm\n	Zoom Link: https://mcgill.zoom.u
 s/j/89914150820\n	In Person: 550 Sherbrooke\, Room 189\n	\n	Abstract: Biomine
 ralization is the formation of inorganic materials by living organisms. It
  is a highly abundant biological phenomenon that occurs in essentially all
  taxonomic groups\, and is studied in many research areas ranging from eco
 logy and geology to materials science and biomedicine. To date\, more than
  70 different types of biominerals are known\, displaying species-specific
  architectures\, as well as wide-ranging chemical compositions and biologi
 cal functions. Biomineralization often occurs as mineral crystal growth wi
 thin extracellular matrix fiber assemblies\, where charged small molecules
 \, peptides\, and large intrinsically disordered proteins guide mineraliza
 tion events. While small-molecule and protein inhibitors broadly prevent s
 oft and compliant tissues from mineralizing\, release from this inhibition
  in the skeleton (bone and enthesis fibrocartilage) occurs through local e
 xpression of enzymes that cleave these inhibitors. Mutations in these enzy
 mes result in inhibitor accumulation leading to debilitating mineralizatio
 n defects and losses of mechanical function in diseases of the skeleton an
 d teeth.\n\nI will present diverse biomineralizing systems and how we thin
 k they are regulated. Mechanical properties of mineralized fibrous biocomp
 osites originate from nanoscale relations of their constituent parts\, and
  often propagate across several hierarchical levels in 3D\, all the way to
  the macroscale. Correlative\, multi-scale 3D imaging approaches are now i
 n common use in structural biology studies\, and our work utilizes these a
 pproaches (including electron microscopy\, particularly FIB-SEM serial-sur
 face-view tomography combined with deep learning-assisted segmentation) to
  better understand at multiple levels how mineralization form organic-inor
 ganic biocomposites having diverse properties and functions.\n
DTSTART:20241105T170000Z
DTEND:20241105T180000Z
SUMMARY:QLS Seminar Series - Marc D McKee
URL:/qls/channels/event/qls-seminar-series-marc-d-mcke
 e-360288
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