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UID:20250806T214709EDT-2980brcAsv@132.216.98.100
DTSTAMP:20250807T014709Z
DESCRIPTION:\n	Maintenance of cardiac function involves a regulatory loop in
  which electrical excitation causes the heart to contract through excitati
 on-contraction coupling\, and the mechanical state of the heart directly a
 ffects its electrical activity through mechano-electric coupling (MEC). Ho
 wever\, in pathological states that alter early or late electro-mechanical
  coordination (i.e.\, disturbances in ECC or repolarisation-relaxation cou
 pling\, RRC)\, MEC may contribute to the initiation and/or sustenance of a
 rrhythmias (mechano-arrhythmogenesis). The molecular identity of specific 
 factors underlying mechano-arrhythmogenesis\, however\, remain undefined. 
 Here I will discuss recent findings from my lab that demonstrate an involv
 ement of alterations in RRC\, transient receptor potential kinase ankyrin 
 1 (TRPA1)\, microtubules\, reactive oxygen species\, and intracellular cal
 cium in ventricular mechano-arrhythmogenesis.\n\nThis seminar will be offe
 red both online and in-person. Details in attached poster.\n
DTSTART:20220408T150000Z
DTEND:20220408T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Tugging at the heart strings: mechanisms of cardiac mecha
 no-arrhythmogenesis
URL:/physiology/channels/event/seminar-tugging-heart-s
 trings-mechanisms-cardiac-mechano-arrhythmogenesis-337531
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