BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250707T163018EDT-9866zH4Vwr@132.216.98.100
DTSTAMP:20250707T203018Z
DESCRIPTION:To attend in person - click here\n\nTo view the livestream\, cl
 ick here.\n\n\nMargaret E. Rice\n\nProfessor\, Neuroscience Institute\, NY
 U Langone\, New York\, USA\n\nAbstract: Dopamine (DA) plays key roles in m
 ovement\, motivation\, mood\, and motor learning. These roles are linked –
  we move because we are motivated to do so. Identifying factors that regul
 ate DA release can provide insight into how DA mediates these effects\, as
  well as how DA dysregulation might contribute to neuropsychiatric disorde
 rs\, including Parkinson’s disease\, depression\, and obesity. Primary tar
 get regions for DA release are the dorsal striatum (dStr) and the nucleus 
 accumbens (NAc\, or ventral striatum). The dStr receives dense innervation
  from midbrain DA neurons in the substantia nigra pars compacta (SNc) and 
 the NAc receives input primarily from the ventral tegmental area (VTA). In
  addition to regulation of striatal DA release by patterned activity of DA
  neurons\, DA release is regulated locally and dynamically at the level of
  DA axons. The most striking local regulator is acetylcholine (ACh) from c
 holinergic interneurons (ChIs)\, which can drive DA release via nicotinic 
 ACh receptors (nAChRs) on DA axons. Other unexpected factors alter DA rele
 ase\, as well\, including the peripheral hormones insulin and leptin\, met
 abolic states including obesity and exercise\, and endogenous GABA\, the m
 ajor inhibitory transmitter discovered by Prof. K.A.C. Elliott. These infl
 uencers will be the focus of this lecture. Together with other local facto
 rs\, these substances and states define the rich\, yet nuanced repertoire 
 of DA transmission patterns and consequent regulation of DA-dependent beha
 viors.\n\n\nThe KAC Elliott Lecture was instituted in honour of Dr. Kennet
 h Allan Caldwell Elliott who was a neurochemist at the MNI (1944-1968). Dr
 . Elliott contributed immensely to the understanding of the basic chemical
  mechanisms of cerebral edema\, epilepsy\, and brain tumours. Importantly\
 , in 1957\, Dr. Elliot and his colleagues identified the role of gamma-ami
 nobutyric acid (GABA)\, now believed to be the major inhibitory transmitte
 r in the brain.\n
DTSTART:20230418T200000Z
DTEND:20230418T210000Z
LOCATION:Montreal Neurological Institute\, CA\, QC\, Montreal\, H3A 2B4\, 3
 801 rue University
SUMMARY:KAC Elliott Lecture: Unexpected regulators of striatal dopamine rel
 ease: insulin\, exercise\, and GABA
URL:/neuro/channels/event/kac-elliott-lecture-unexpect
 ed-regulators-striatal-dopamine-release-insulin-exercise-and-gaba-342349
END:VEVENT
END:VCALENDAR