BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250513T170326EDT-2431VjgZgM@132.216.98.100 DTSTAMP:20250513T210326Z DESCRIPTION:The Killam Seminar Series presents 'Protein Misfolding meets Ce rebrovascular Disease”\n\nRegistration available here. \n\nSpeaker: Sandra Black\n\nProfessor\, Department of Medicine\, Sunnybrook Health Sciences Centre\, Canada\n\nAbstract: I will summarize some key advances in biomark er discovery in Alzheimer’s Disease detected by multimodal brain imaging t echniques including volumetric MRI and molecular PET\, neuropathology part icularly TDP43 deposition\, genetic risk markers and\, more recently\, pla sma protein profiles. I will also highlight the complex relationships betw een AD\, itself quite heterogeneous\, and Cerebrovascular Disease. In part icular I will review the subtypes of SVD\, including perivascular spaces a nd periventricular white matter disease associated with deep venular colla genosis\, and illustrate the behavioural relevance of injury to the cholin ergic projections.\n\nBio: Dr. Black has had continual peer-reviewed fundi ng since 1986. Her research focuses on the cognitive sequelae of stroke an d stroke recovery\, the differential diagnosis of dementia\, the use of ne uroimaging techniques to elucidate brain-behaviour relationships in stroke and dementia\, and more recently\, imaging-genetics correlations.\n\nHer funding sources include the Alzheimer’s Drug Discovery Foundation\, Brain Canada\, Canadian Institutes of Health Research (CIHR)\, Heart and Stroke Foundation of Canada\, National Institutes of Aging and Weston Brain Insti tute.\n\nShe is conducting prospective studies on the utility of quantitat ive structural and functional imaging in diagnosis and monitoring of mild cognitive impairment\, Alzheimer's disease\, vascular dementia\, frontotem poral dementia\, and Parkinson’s-Lewy body disease\, and on the interactio ns of Alzheimer's disease and cerebrovascular disease. She is also an acti ve clinical trialist with experience in more than 60 clinical and pharmace utical trials.\n\nShe is leading multicentre Canadian trials using amyloid imaging in patients with Alzheimer’s and Parkinson’s disease with moderat e to severe white matter disease. In these trials\, she is using ocular bi omarkers\, genetics\, multimodal magnetic resonance imaging and neuropsych ological testing. She is also concluding a repurposing trial of angiotensi n receptor blockers versus angiotensin converting enzyme inhibitors in hyp ertensive patients with Alzheimer’s disease.\n\nAs of June 2016\, Dr. Blac k has over 470 publications (403 peer-reviewed)\, a Scopus H-index of 72\, Google Scholar H-index of 89 and 28\,726 citations. Over the last 25 year s\, she has led multidisciplinary research teams in studies of stroke and dementia. She has mentored many young faculty and trainees\, including 36 postdoctoral fellows\, 18 PhD students and 15 master’s students\, earning outstanding mentorship awards from U of T’s Institute of Medical Sciences and department of medicine.\n\nHer CIHR-funded multidisciplinary\, multimo dality longitudinal study of 1\,279 patients with Alzheimer’s disease and other dementias has investigated brain-behaviour relationships\, particula rly the role of small vessel disease\, and the utility of neuroimaging for diagnosis and monitoring treatment response (including 170 patients follo wed to autopsy). This invaluable archive has generated and contributed to 191 peer-reviewed publications in high-quality journals with trainees as f irst authors on more than 70 of those. These include reports of novel gene mutations in frontotemporal dementia and Lewy body disease.\n\n\nSupporte d by the generosity of the Killam Trusts \, The Neuro’s Killam Seminar ser ies hosts outstanding guest speakers whose research is of interest to the scientific community at The Neuro and 91Ƶ.\n DTSTART:20220308T210000Z DTEND:20220308T220000Z SUMMARY:Killam Seminar Series presents: Protein Misfolding meets Cerebrovas cular Disease URL:/neuro/channels/event/killam-seminar-series-presen ts-protein-misfolding-meets-cerebrovascular-disease-338065 END:VEVENT END:VCALENDAR