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UID:20250815T141228EDT-9726drapV0@132.216.98.100
DTSTAMP:20250815T181228Z
DESCRIPTION:Prof Jorge Riera\, PhD - Biomedical Engineering - Florida Inter
 national University (Miami)\nUnderstanding BOLD signal genesis in focal ep
 ilepsy\nAbstract - Blood-oxygen-level dependent (BOLD) activation evoked b
 y interictal epileptiform discharges (IEDs) has been employed as a clinica
 l biomarker to identify the seizure-onset zones in patients with intractab
 le focal epilepsy. However\, the existence of BOLD deactivations in certai
 n brain regions confounds the analysis and interpretation of the BOLD sign
 als\, thereby reducing the value of EEG-fMRI in the process of planning an
  epilepsy surgery. In this study\, we investigated the causal relationship
 s between the IED-related BOLD activation and deactivation in a preclinica
 l rat model of focal cortical dysplasia\, as well as explored their relati
 onships with alterations in the resting state networks (RSNs). Also\, we e
 mployed a metabolically-coupled balloon model to evaluate the neuro-vascul
 ar/metabolic coupling in this preclinical model. The model included modula
 tory effects of changes in tissue oxygenation\, capillary dynamics and var
 iable O2 extraction fraction incorporated in. Using intracranial recording
 s (LFP/MUA\, CBF\, CBV\, [Deoxy-Hb]) from epileptogenic regions\, we found
  that: a) the most significant contribution to the CBF responses comes fro
 m high-oscillatory neuronal activities and b) crucial parameters of the bi
 ophysical model are significantly different between epileptic and normal c
 ortices. Finally\, histological studies provided us insights about the cel
 lular basis underlying such abnormalities in the neuro-vascular/metabolic 
 coupling\, paving the ways for a future therapeutic control using optogene
 tics. We discuss these results in terms of recent findings from our group 
 about vessel network changes in pedriatic epilepsy.\nMore information: htt
 ps://bme.fiu.edu/faculty-staff/jorge-riera/\n
DTSTART:20150722T153000Z
DTEND:20150722T163000Z
LOCATION:de Grandpré Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Brain Imaging Lecture - Prof Jorge Riera - Understanding BOLD signa
 l genesis in focal epilepsy
URL:/bic/channels/event/brain-imaging-lecture-prof-jor
 ge-riera-understanding-bold-signal-genesis-focal-epilepsy-253981
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